High-Yielding Synthesis of 3-Alkoxycarbonyl- and 3-Carboxamido-3-tropene Derivatives in Homogeneous Carbonylation Reactions of 3-Iodo-2-tropene

3-Iodo-2-tropene, synthesized from the corresponding ketone (tropinone) via its hydrazone, was carbonylated in palladium-catalyzed alkoxy- and aminocarbonylation reactions. The new synthetic approach provided the corresponding 3-carboxylic acid derivatives of pharmacological importance in chemospecific reactions and isolated in up to 87 % yields.