Synthesis of 8,16-Ethanoretinals and Their Interactions with Apoprotein of Phoborhodopsin from Natronobacterium pharaonis

Akimori Wada; Yoshimi Takakura; Kenta Yamazaki; Tetsuo Takahashi; Masayoshi Ito

doi:10.2174/1570178043488789

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis of 8,16-Ethanoretinals and Their Interactions with Apoprotein of Phoborhodopsin from Natronobacterium pharaonis
Authors: Akimori Wada¹, Yoshimi Takakura², Kenta Yamazaki³, Tetsuo Takahashi⁴ and Masayoshi Ito⁵
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¹ Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada, Kobe 658-8558, Japan. ² Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada, Kobe 658-8558, Japan. ³ Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada, Kobe 658-8558, Japan. ⁴ Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada, Kobe 658-8558, Japan. ⁵ Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada, Kobe 658-8558, Japan.
Source: Letters in Organic Chemistry, Volume 1, Issue 1, Jan 2004, p. 59 - 62
DOI: https://doi.org/10.2174/1570178043488789
- Available online: 01 Jan 2004

Abstract

Several 8,16-Ethanoretinals 3 were synthesized from cyclohexanones. From the binding experiments of these analogs with apoprotein of phoborhodopsin, it was found that retinal was incorporated as 6s-trans conformation in the protein and the fine structure in absorption spectra of pigments were dependent on the coplanarity of the conjugated polyene structure in the chromophore.

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2004-01-01

2025-10-03

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Article Type: Review Article

Keyword(s): chromophore; ethanoretinal; phoborhodopsin; retinal analog; s-trans conformation

Synthesis of 8,16-Ethanoretinals and Their Interactions with Apoprotein of Phoborhodopsin from Natronobacterium pharaonis

Abstract

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