Synthesis of N-Aryl Indolines from 2-Fluorobenzaldehyde Dimethylhydrazone Derivatives: Approach to Preparation of C(aryl)-N(Amine) Bond Atropisomeric Amines

Takashi Mino; Youichi Tanaka; Youtaro Hattori; Motoko Tanaka; Masami Sakamoto; Tsutomu Fujita

doi:10.2174/1570178043488699

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis of N-Aryl Indolines from 2-Fluorobenzaldehyde Dimethylhydrazone Derivatives: Approach to Preparation of C(aryl)-N(Amine) Bond Atropisomeric Amines
Authors: Takashi Mino¹, Youichi Tanaka², Youtaro Hattori³, Motoko Tanaka⁴, Masami Sakamoto⁵ and Tsutomu Fujita⁶
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¹ Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan. ² Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan. ³ Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan. ⁴ Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan. ⁵ Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan. ⁶ Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan.
Source: Letters in Organic Chemistry, Volume 1, Issue 1, Jan 2004, p. 67 - 69
DOI: https://doi.org/10.2174/1570178043488699
- Available online: 01 Jan 2004

Abstract

2-(1-indolinyl)benzaldehyde dimethylhydrazones are prepared by nucleophilic aromatic substitution of the corresponding 2-fluorobenzaldehyde dimethylhydrazones with lithiated indoline in good yields.

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2004-01-01

2025-10-03

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Article Type: Review Article

Keyword(s): aminophosphine; atropisomer; hydrazone; indoline; nucleophilic aromatic substitution

Synthesis of N-Aryl Indolines from 2-Fluorobenzaldehyde Dimethylhydrazone Derivatives: Approach to Preparation of C(aryl)-N(Amine) Bond Atropisomeric Amines

Abstract

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