Microwave-Assisted Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles

Khalid M. Khan; Zia-Ullah; Mubeen Rani; Shahnaz Perveen; Syed Moazzam Haider; Muhammad Iqbal Choudhary; Atta-ur-Rahman; Wolfgang Voelter

doi:10.2174/1570178043488608

ISSN: 1570-1786
E-ISSN: 1875-6255

Microwave-Assisted Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles
Authors: Khalid M. Khan¹, Zia-Ullah², Mubeen Rani³, Shahnaz Perveen⁴, Syed Moazzam Haider⁵, Muhammad Iqbal Choudhary⁶, Atta-ur-Rahman⁷ and Wolfgang Voelter⁸
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¹ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ² H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ³ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁴ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁵ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁶ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁷ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁸ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
Source: Letters in Organic Chemistry, Volume 1, Issue 1, Jan 2004, p. 50 - 52
DOI: https://doi.org/10.2174/1570178043488608
- Available online: 01 Jan 2004

Abstract

Recent advances in technology have now made microwave energy a more efficient means of heating reactions. Chemical transformations that took hours, or even days, to complete can now be accomplished in minutes. Microwave energy offers numerous benefits for performing synthesis including increased reaction rates, yield enhancements, and cleaner chemistries. 2,5-Disubstituted-1,3,4-oxadiazoles were synthesized under microwave irradiation and by conventional heating and were structurally characterized by 1H-NMR, EI, IR, UV and elemental analysis.

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2004-01-01

2025-10-04

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Article Type: Review Article

Keyword(s): disubstituted; microwave-irradiation; oxadiazole; phosphorous oxychloride

Microwave-Assisted Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles

Abstract

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