Novel Anthraquinone-Carbohydrate Hybrids: The Significant Improvement of the DNA Photocleaving Activity and the Cytotoxic Selectivity

Kazunobu Toshima; Yoko Nakajima; Yutaka Maeda; Shuichi Matsumura

doi:10.2174/1570178043488581

ISSN: 1570-1786
E-ISSN: 1875-6255

Novel Anthraquinone-Carbohydrate Hybrids: The Significant Improvement of the DNA Photocleaving Activity and the Cytotoxic Selectivity
Authors: Kazunobu Toshima¹, Yoko Nakajima², Yutaka Maeda³ and Shuichi Matsumura⁴
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¹ Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. ² Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. ³ Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. ⁴ Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Source: Letters in Organic Chemistry, Volume 1, Issue 1, Jan 2004, p. 31 - 33
DOI: https://doi.org/10.2174/1570178043488581
- Available online: 01 Jan 2004

Abstract

Novel anthraquinone-carbohydrate hybrids were designed and synthesized as artificial DNA photocleavers. They were found to show high DNA cleaving activity under irradiation with a long wavelength UV light without any additives and also exhibited selective cytotoxicity against HeLa S3 cancer cells with the photoirradiation.

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2004-01-01

2025-10-04

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Article Type: Review Article

Keyword(s): anthraquinone; cancer cells; carbohydrate; cytotoxicity; dna cleavage; photoirradiation

Novel Anthraquinone-Carbohydrate Hybrids: The Significant Improvement of the DNA Photocleaving Activity and the Cytotoxic Selectivity

Abstract

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