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2000
Volume 23, Issue 1
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

Sustainable green heterocyclic compounds featuring fused bi-, tri-, and tetracyclic systems containing pyrimidine-barbituric acid rings were synthesized the Hantzsch reaction using a simple and efficient method. The one-pot, three-component reaction involved bis-aldehydes, barbituric acid, and substituted amines, and was carried out under microwave irradiation without the use of a catalyst. The reactions proceeded smoothly, affording the desired products in high yields with straightforward workups. This study emphasizes the importance of green chemistry principles in the synthesis of fused pyrimido[4,5-]pyrimidine systems, highlighting advantages, such as environmental friendliness, operational simplicity, efficiency, and safety.

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2025-08-18
2026-02-27

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/content/journals/loc/10.2174/0115701786396085250807104805
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Eco-Friendly Microwave-Assisted Synthesis of Fused Pyrimido[4,5-d]Pyrimidine Derivatives via a Catalyst-Free Hantzsch Multicomponent Reaction
Lett. Org. Chem. 23, 44 (2026); https://doi.org/10.2174/0115701786396085250807104805
/content/journals/loc/10.2174/0115701786396085250807104805
/content/journals/loc/10.2174/0115701786396085250807104805
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  • Article Type:     Research Article
Keyword(s): Catalyst-free; Fused nitrogen heterocycles; Green Chemistry; Hantzch reaction; Microwave irradiation; pyrimido[4,5-d]pyrimidine

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