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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Fe3O4@TiO2 Magnetic Nanocomposite Catalyzed Sustainable Synthesis of Dihydro[1]benzopyrano[h][1]benzopyrans and Antimicrobial Activity Evaluation
- Source: Letters in Organic Chemistry, Volume 22, Issue 8, Aug 2025, p. 623 - 632
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- 17 Oct 2024
- 07 Nov 2024
- 29 Jan 2025
Abstract
The present study's exploration of innovative techniques for the production of heterocyclic scaffolds was prompted by the significance of [1]benzopyran motifs in bioactive chemicals. Given the appealing aspects of creating innovative methodological techniques while working with heterogeneous nanocatalysts, we desired to use this method to synthesize a number of dihydro[1]benzopyrano[h][1]benzopyrans. This work set out to demonstrate the prepared Fe3O4@TiO2 nanocomposite's catalytic efficacy as a magnetically separable catalyst in the production of dihydro[1]benzopyrano[h][1]benzopyrans. 3,9-diamino-1,7-diaryl-1,7-dihydro[1]benzopyrano[8,7-h][1]benzopyran-2,8-dicarbonitriles were obtained in an easy-to-manage manner by utilizing a Fe3O4@TiO2 nanocomposite as an effective catalyst in an aqueous medium at 70°C. The in vitro antimicrobial activities of some synthesized compounds were tested by the disk diffusion method. A number of target molecules, dihydro[1]benzopyrano[h][1]benzopyrans, were successfully synthesized in high yields. The results of the antimicrobial experiment showed encouraging antibacterial effects. This study offered significant advantages of high yield and practical methodology for the synthesis of dihydro[1]benzopyrano[h][1]benzopyrans. The utilization of aqueous ethanol as an environmentally friendly medium and the Fe3O4@TiO2 nanocomposite as a magnetically separable catalyst are examples of how this work adhered to the principles of green chemistry. The biological effectiveness of some of the produced compounds was tested against both Gram-negative and Gram-positive bacteria.
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