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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Celecoxib Catalyzed the Coupling Reaction of Epoxide and CO2
- Source: Letters in Organic Chemistry, Volume 21, Issue 7, Jul 2024, p. 611 - 619
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- 01 Jul 2024
Abstract
In this study, high yields of various cyclic carbonates are obtained by employing the drug celecoxib to promote the coupling reaction of CO2 and epoxide using tetrabutylammonium bromide. This strategy enables the synthesis of benzoic acid, phenylpropiolic acid, and 2, 4- quinazolinedione. In addition, the model reaction mechanism is proposed.
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