Isochromanones and Isobenzofuranone from Arctic Fungus Gyoerffyella sp. CPCC 401434

Jun Hu; Yu Liu; Ming Chen; Zhe Guo; Ling Ma; Tao Zhang; Shan Cen; Fang Wang; Liyan Yu; Dewu Zhang

doi:10.2174/0115701786235197250217102621

ISSN: 1570-1786
E-ISSN: 1875-6255

Isochromanones and Isobenzofuranone from Arctic Fungus Gyoerffyella sp. CPCC 401434
Authors: Jun Hu¹, Yu Liu¹, Ming Chen², Zhe Guo¹, Ling Ma¹, Tao Zhang¹, Shan Cen¹, Fang Wang², Liyan Yu¹ and Dewu Zhang¹
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¹ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China ; ² Institute of Traditional Chinese Medicine, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China
Source: Letters in Organic Chemistry, Volume 22, Issue 9, Sep 2025, p. 713 - 716
DOI: https://doi.org/10.2174/0115701786235197250217102621
- Received: 30 Sep 2024
- Accepted: 18 Dec 2024
- Available online: 26 Feb 2025

Abstract

A new isochromanone, (3R,4R)-3,6,8-trihydroxy-3,4,5-trimethylisochroman-1-one (1), together with six known isochromanones (2-7) and one known isobenzofuranone (8), were obtained from the Arctic fungus Gyoerffyella sp. CPCC 401434. The chemical structures were determined on the basis of extensive NMR and MS data analyses. All the compounds were first reported from the genus Gyoerffyella. Compounds 6 and 7 showed significant cytotoxic activities. Compounds 2, 3, 5, 8, 9, and 11 displayed significant anti-IAV (H1N1) activities, similar to that of ribavirin.

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/content/journals/loc/10.2174/0115701786235197250217102621

Isochromanones and Isobenzofuranone from Arctic Fungus Gyoerffyella sp. CPCC 401434

Lett. Org. Chem. 22, 713 (2025); https://doi.org/10.2174/0115701786235197250217102621

/content/journals/loc/10.2174/0115701786235197250217102621

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Supplementary material is available on the publisher’s website along with the published article.

Article Type: Research Article

Keyword(s): Arctic fungus; bioactive activity; Gyoerffyella; isobenzofuranone; isochromanone; structural elucidation

Isochromanones and Isobenzofuranone from Arctic Fungus Gyoerffyella sp. CPCC 401434

Abstract

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Supplementary material is available on the publisher’s website along with the published article.

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