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2000
Volume 21, Issue 13
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

The increase in multi-drug resistant (MDR) pathogens and the decline in the number of new antibiotics in the production pipeline pose a serious threat to our ability to treat infectious diseases. In this new landscape, once treatable diseases are now potentially life-threatening. This impending danger requires that urgent attention should be given to developing alternative strategies for combating MDR bacteria. A novel alternative is the use of predatory bacteria, spp, that naturally prey on Gram-negative bacteria, including MDR Enterobacteriaceae. has been shown to be non-pathogenic in animal models and on human cell lines, supporting its feasibility to be used to treat infections in animals and possibly humans. This document reviews various aspects of biology, including its unique life cycle, “predatory toolbox”, prey range, and recent research advances exploring as an antimicrobial agent, stepping towards its use in human therapy. We also discuss the advantages and limitations of using therapy and the strategies to overcome these limitations.

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2023-09-19
2025-10-19

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/content/journals/lddd/10.2174/1570180820666230912161923
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Bdellovibrio bacteriovorus Therapy, an Emerging Alternative to Antibiotics
Letters in Drug Design & Discovery 21, 2505 (2024); https://doi.org/10.2174/1570180820666230912161923
/content/journals/lddd/10.2174/1570180820666230912161923
/content/journals/lddd/10.2174/1570180820666230912161923
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  • Article Type:     Review Article
Keyword(s): antibiotic resistance; Bdellovibrio bacteriovorus; biotherapy; flagella; multi-drug resistance pathogen; Predatory bacteria

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