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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Antiproliferative Activity of New Polyoxo 2-Benzyl-2,3- dihydrobenzofurans and Their Related Compounds
- Source: Letters in Drug Design & Discovery, Volume 10, Issue 9, Nov 2013, p. 886 - 894
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- 01 Nov 2013
Abstract
A set of new polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds, including 2- benzylbenzofuran-3(2H)-ones and 2-benzylbenzofurans, were designed and synthesized. Their antiproliferative activities were evaluated against human gastric cancer (SGC-7901), human fibrosarcoma (HT-1080) and human oral epidermoid carcinoma (KB) cell lines in vitro. Preliminary results showed that some polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds had significant activity comparable with that of cisplatin.
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