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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biological Evaluation of 1, 3-Dihydroxyxanthone Mannich Base Derivatives as Potential Antitumor Agents
- Source: Letters in Drug Design & Discovery, Volume 10, Issue 8, Oct 2013, p. 689 - 698
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- 01 Oct 2013
Abstract
A novel series of Mannich bases of 1, 3-dihydroxyxanthone derivatives were designed and synthesized. The chemical structures of the compounds were characterized by IR, MS and NMR spectra. Their in vitro toxicities on six tumor cell lines including NCI-H460 (lung cancer), TCA-8113 (tongue squamous cell carcinomas), BEL-7402 (liver cancer), HepG2 (hepatocarcinoma), SGC-7901 (gastric carcinoma) and T24 (urinary bladder carcinoma) were studied through MTT assay. The results showed that most of the compounds displayed mild to good inhibitory activities on the cancer cell lines. Some preliminary structure-activity relationships were also discussed.
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