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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Inhibitory Effects of Substituted Cinnamic Acid Esters on Mushroom Tyrosinase
- Source: Letters in Drug Design & Discovery, Volume 10, Issue 6, Jul 2013, p. 529 - 534
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- 01 Jul 2013
Abstract
A series of substituted cinnamic acid esters were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. Compound 8 was found to be the most potent inhibitor with IC50 value of 5.60μM. Preliminary structure activity relationships (SARs) were concluded. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 8 was anti-competitive inhibitor.
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