Diversity in Antibacterial Activity of Thiosemicarbazides Derived from 3-Chlorobenzhydrazide

3-Chlorobenzoic acid hydrazide was reacted with different aryl isothiocyanates to give the corresponding 1-(3- chlorobenzoyl)-4-substituted thiosemicarbazides 1-16. Reaction yields ranged from 74 to 96%. Structures of the synthesized compounds were defined on the basis of ¹H NMR and IR spectra. As it was showed the antibacterial activity of the obtained compounds was limited only towards Gram-positive bacteria. As regards B. cereus ATCC 10876, 1-(3- chlorobenzoyl)-4-(3,5-dichlorophenyl)thiosemicarbazide (8) was 16 times more active than ampicillin and 8 times more active than cefuroxime.