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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09
- Source: Letters in Drug Design & Discovery, Volume 10, Issue 6, Jul 2013, p. 477 - 485
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- 01 Jul 2013
Abstract
A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.
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