Skip to content
2000
Volume 7, Issue 10
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

A series of 48 commercial benzaldehydes have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv, using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Benzaldehydes 39 and 41 exhibited a significant activity at 3.12 μg/mL. Although commercial benzaldehydes have been largely used by many research groups in search of news TB-drugs, they had not been tested previously against Mycobacterium tuberculosis. This study adds important information to the rational design of new lead anti-TB drugs.

© Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/lddd/10.2174/1570180811007010754
2010-12-01
2025-09-04

  • From This Site

    /content/journals/lddd/10.2174/1570180811007010754
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

/content/journals/lddd/10.2174/1570180811007010754
Loading

  • Article Type:     Research Article
Keyword(s): Alamar Blue assay; Antimycobacterial evaluation; BACTEC; Benzaldehydes; Cell Viability Assay; Cytotoxicity; DMSO; drug-resistant tuberculosis; Drugs; Isoniazid; MABA; MDR-TB; Mosmans's MTT; multidrug-resistant tuberculosis; Mycobacterium tuberculosis; Rifampin; RPMI 1640; SAR; Tuberculosis; XDR-TB

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test