Synthesis and In Vitro Antimicrobial Evaluation of 4-alkyl/aryl-1-(3-phenoxypropionyl)-thiosemicarbazides

Eight new 4-alkyl/aryl-1-(3-phenoxypropionyl)-thiosemicarbazides were synthesized by condensation of 3- phenoxypropionic acid hydrazide with related isothiocyanates. All compounds were tested in vitro for their antibacterial and antifungal activity. One compound, 4-(4-chlorophenyl)-1-(3-phenoxypropionyl)-thiosemicarbazide, showed high level of activity against Gram-positive species, MICs range 12.5-50 μg/mL. Semiempirical calculations of geometries, energies, and QSAR parameters have been determined in hope to get insight into different biological activity of closely related isomers.