3',4'-Dihydrospiro[piperidine-4,2'-(1'H)quinoline] Derivatives as New Antioxidant Agents with Acetylcholinesterase Inhibitory Property

In vitro radical-cation scavenging capacity and anti-AChE activities of 19 piperidine derivatives, including dihydrospiro[ piperidine-4,2'(1'H)quinolines] 7-19 and their precursor 4-allyl-4-arylaminopiperidines 1-6 were reported. Their data of bioassays and calculated logP and TPSA parameters showed promising drug-like properties. The best radical scavenging compound (TEAC 1.73 ± 0.01), 6-methyl-3',4'- dihydrospiro[piperidine-4,2'(1'H)quinoline] 8 showed IC50 value of 62.5 μM (20.0 μg/mL) using AChE assay.