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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics
- Source: Letters in Drug Design & Discovery, Volume 6, Issue 5, Jul 2009, p. 393 - 396
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- 01 Jul 2009
Abstract
Two hydrolytically activated anthraquinone-diclofenac prodrugs have been designed and synthesized. Both prodrugs show significant binding capability to hydroxyapative (HAP), the major component of bone, and hydrolytically activity in simulation physiological conditions in vitro.
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