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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Discovery of Novel CYP17 Inhibitors for the Treatment of Prostate Cancer with Structure-Based Drug Design
- Source: Letters in Drug Design & Discovery, Volume 6, Issue 5, Jul 2009, p. 337 - 344
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- 01 Jul 2009
Abstract
It has been shown that prostate cancer is associated with elevated androgen biosynthesis; therefore, inhibiting the activity of Cytochrome P450 17 (CYP17) may prevent progression of prostate cancer. In this study we identified, using in silico and experimental methods, two novel steroidal and non-steroidal lead compounds that inhibit the activity CYP17.
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