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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biological Evaluation of Novel Hydroxylphenethyl-S-DACOs as High Active Anti-HIV Agents
- Source: Letters in Drug Design & Discovery, Volume 10, Issue 3, Mar 2013, p. 271 - 276
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- 01 Mar 2013
Abstract
A novel 5-alky-6-(cyclohexylmethyl)-2-((2-hydroxy-2-phenylethyl)thio)-pyrimidin-4(3H)-one derivatives were synthesized and their ability to inhibit HIV evaluated . The screening results revealed that compounds 2a-g had a favorable property in inhibiting HIV. The compounds 2b, in particular, showed a special potent anti-HIV activities with EC50 values of 0.003μM and CC50 values of 200 μM. Preliminary structure-activity relationship (SAR) and molecular modeling analyses of these newly synthesized hydroxylphenethyl-S-DACOs are also discussed.
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