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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives
- Source: Letters in Drug Design & Discovery, Volume 10, Issue 2, Feb 2013, p. 155 - 163
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- 01 Feb 2013
Abstract
A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
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