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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles
- Source: Letters in Drug Design & Discovery, Volume 9, Issue 10, Dec 2012, p. 942 - 946
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- 01 Dec 2012
Abstract
Novel 3,5-disubstituted 1,2,4-oxadiazoles 4a-4j were prepared from commercially available chlorosalicylaldehyde and screened for their cytotoxicity properties using brine shrimp (Artemia salina) bioassay and compared with the standard podophyllotoxin. The oxadiazoles 4a, 4c, 4e and 4h exhibited cytotoxicity activity in the series.
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