Design of Peptidomimetic Based DPP-IV Inhibitors, Devoid of CYP Liabilities

Pradip Jadav; Rajesh Bahekar; Shailesh R. Shah; Dipam Patel; Amit Joharapurkar; Kiran Shah; Shruti Bhardwaj; Kishan Patel; Kaushil Patel; Rajendra Chopade; Mubeen Shaikh; Kalapatapu V.V.M. Sairam; Mukul Jain

doi:10.2174/157018012803307932

ISSN: 1570-1808
E-ISSN: 1875-628X

Design of Peptidomimetic Based DPP-IV Inhibitors, Devoid of CYP Liabilities
By Pradip Jadav, Rajesh Bahekar, Shailesh R. Shah, Dipam Patel, Amit Joharapurkar, Kiran Shah, Shruti Bhardwaj, Kishan Patel, Kaushil Patel, Rajendra Chopade, Mubeen Shaikh, Kalapatapu V.V.M. Sairam and Mukul Jain
Source: Letters in Drug Design & Discovery, Volume 9, Issue 9, Nov 2012, p. 867 - 873
DOI: https://doi.org/10.2174/157018012803307932
- Available online: 01 Nov 2012

Abstract

A peptidomimetic based cyanopyrrolidine derivatives are reported as potent and selective DPP-IV inhibitors. Some of the test compounds (10l and 10m) showed excellent potency and selectivity towards DPP-IV over various serine proteases, without CYP inhibition.

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2012-11-01

2025-12-11

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Article Type: Research Article

Keyword(s): cyanopyrrolidine; CYP; DPP-IV inhibitors; Peptidomimetic; Selectivity

Design of Peptidomimetic Based DPP-IV Inhibitors, Devoid of CYP Liabilities

Abstract

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