New Class of Triazole Derivatives and Their Antimicrobial Activity

A new series of 1,2,4-triazole derivatives 3a-i of (E)-4-(4-substitutedbenzylideneamino)-3-((5-phenyl-1,3,4- oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione (2) were synthesized, deriving from 4-amino-3-((5-phenyl-1,3,4- oxadiazol-2-yl)methyl-1H-1,2,4-triazole-5(4H)-thione (1). The compounds were elucidated by IR, 1H NMR, 13C NMR, MS and elemental analyses. These compounds were screened for their antimicrobial activity. Among the synthesized compounds (E)-4-(4-chlorobenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-(morpholinmethyl)-1H-1,2,4- triazole-5(4H)-thione, 3c was found to exhibit most potent In vitro antimicrobial activity with minimum inhibitory concentrations (MIC) of 1.56, 3.125, 1.56, 25, 25 and 25 μg/ml against E. coli, S. typhimurium, L. monocytogenes, S. aureus, P. aeruginosa and S. pyogenes respectively. Compound (E)-4-(benzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol- 2-yl)methyl)-2-(morpholinmethyl)-1H-1,2,4-triazole-5(4H)-thione 3a was found to exhibit most potent In vitro antifungal activity with MICs 0.78 and 0.097 μg/ml against C. albicans and F. solani.