Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator

Xin Deng; Xinxin Zhao; Jing Han; Jingjie Wang; Wenlong Huang; Hai Qian; Liang Ge

doi:10.2174/157018012800389386

ISSN: 1570-1808
E-ISSN: 1875-628X

Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator
Authors: Xin Deng¹, Xinxin Zhao², Jing Han³, Jingjie Wang⁴, Wenlong Huang⁵, Hai Qian⁶ and Liang Ge⁷
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¹ Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, People’s Republic of China. ² Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, People’s Republic of China. ³ Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, People’s Republic of China. ⁴ Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, People’s Republic of China. ⁵ Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, People’s Republic of China. ⁶ Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, People’s Republic of China. ⁷ Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, People’s Republic of China.
Source: Letters in Drug Design & Discovery, Volume 9, Issue 5, Jun 2012, p. 489 - 493
DOI: https://doi.org/10.2174/157018012800389386
- Available online: 01 Jun 2012

Abstract

Irritable bowel syndrome is the most common functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort in association with a change in bowel habit. 5-HT receptor modulators have been developed as IBS therapeutic agents and proved to be effective in the treatment of the disease. In this letter, 12 berberine derivatives were designed and synthesized as 5-HT receptor modulators. Preliminary biological tests suggested that the new compounds exhibited promising activity for IBS therapy.

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2012-06-01

2025-09-14

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Article Type: Research Article

Keyword(s): Berberine Derivatives; CMC-Na solution; gastrointestinal (GI) disorder; intestinal flora; Irritable bowel syndrome (IBS); isoquinoline alkaloid; plasma 5-HT; tetrahydroberineper

Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator

Abstract

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