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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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A QSAR Study on Some Thiophene Derivatives Acting as Anti-HCV Agents
- Source: Letters in Drug Design & Discovery, Volume 9, Issue 4, May 2012, p. 389 - 396
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- 01 May 2012
Abstract
A quantitative structure- activity relationship (QSAR) study has been made on a series of thiophene derivatives acting as anti-HCV agents. Significant correlations are found between anti-HCV potencies and some physicochemical parameters. The study reveals that the activity can be controlled by molecular connectivity, Hammett constant, and some indicator variables. Using the correlations obtained, some new prospective compounds having high potency have been predicted.
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