Full text loading...
- ISSN: 1570-1808
- E-ISSN: 1875-628X
-
Cytotoxicity Study on Some Synthetic Aromatic Esters of 4'-Demethyl-4-deoxypodophyllotoxin
- Source: Letters in Drug Design & Discovery, Volume 8, Issue 9, Nov 2011, p. 857 - 860
-
- 01 Nov 2011
Abstract
To search for potential anti-cancer analogs, 16 aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin (6a-p) were synthesized and tested their cytotoxicity on six cancer cell lines. The results indicated that all derivatives showed potent cytotoxic activity against A-549 cell line with IC50 values of 0.00009-0.037 μg/mL.
© Bentham Science Publishers