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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Antibacterial Agents
- Source: Letters in Drug Design & Discovery, Volume 8, Issue 9, Nov 2011, p. 816 - 821
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- 01 Nov 2011
Abstract
A series of andrographolide (Andro) derivatives (3-14) were designed, synthesized and screened for their antibacterial activities against both gram-positive and gram-negative bacteria in vitro. The most promising compounds 14a-c exhibited at least eight-fold stronger antibacterial activities compared to Andro. Especially, Compound 14a, which showed 32-fold stronger antibacterial activity than Andro, has a potency to be a new lead.
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