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2000
Volume 8, Issue 6
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

We report the synthesis and evaluation of a novel PPARδ agonist, compound 12a, characterized by a benzisoxazole ring. Compound 12a exhibited a potent human PPARδ transactivation activity (EC50: 0.011 μM). Preliminary biological testing suggests that compound 12a has significant HDL-cholesterol elevating effect in an animal model of dyslipidemia.

© Bentham Science Publishers
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/content/journals/lddd/10.2174/157018011795906802
2011-07-01
2025-10-12

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  • Article Type:     Research Article
Keyword(s): Ames test; apolipoprotein A-I Milano/phospholipid complex; atherosclerotic cardiovascular disease; Benzisoxazole ring; Compound 12a; Diabetes; dyslipidemia; HDL Cholesterol; Lipoprotein; niacin; Obesity; Peroxisome; PPARδ Agonist; Proliferator-Activated; Receptor; Transactivation

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