Synthesis of Cyclodextrin Derivatives of Amino-(thiazolyl) Coumarins as Potential Antimicrobial Agents

A series of new cyclodextrin linked coumarins was synthesized (12a-g) and evaluated for th ei r antimicrobial activity. All the compounds investigated have shown significant antimicrobial a c t iv i ty against gram-positive and gramnegative bacterial strains as well as a few fungal strains. The compounds exhibited upto 4-fold improved biological activity than their precursors. The results suggest that the improvement in bioavailability is responsible for the enhanced biological activity.