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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Estrone (E1) Based Esters as Potential Inhibitors of Type 3 17β- hydroxysteroid Dehydrogenase (17β-HSD3) in the Treatment of Hormone-Dependent Prostate Cancer
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 9, Nov 2010, p. 650 - 656
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- 01 Nov 2010
Abstract
We report the use of estrone (E1)-based compounds in the search for inhibitors of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds are good inhibitors of 17β-HSD3 and a number were found to be equipotent to the standard inhibitors used within the current study.
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