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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 8, Oct 2010, p. 551 - 555
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- 01 Oct 2010
Abstract
A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cytotoxicity activity for HL-60. The results also demonstrated that compound 3f seems to be selective to HL-60 cell line, appearing as a good prototype for an antileukemia lead molecule.
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