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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Lithocholic Acid Derivative as a Model for Artificial Receptors: A Raman Study
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 8, Oct 2010, p. 610 - 617
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- 01 Oct 2010
Abstract
Two lithocholic acid (LCA) derivatives — mono- and diesters (newly synthetised) — are studied for their main conformational preferences, by Raman spectroscopy coupled to theoretical (DFT) methods. Raman bands characteristic of each compound were assigned, allowing an accurate and rapid identification of this kind of systems. The conformational preferences of the LCA diester were related with its ability to function as a model for artificial receptors, displaying a tailored structural profile.
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