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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Triterpenes from Gloeophyllum odoratum as Potential Leads Towards Potent Thrombin Inhibitors
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 7, Aug 2010, p. 521 - 527
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- 01 Aug 2010
Abstract
A bioassay oriented fractionation of Gloeophyllum odoratum dry extract has led to the isolation of three active fractions. On the basis of spectroscopic data, MS spectroscopy and microanalysis a new tetracyclic triterpene: 3α- hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, together with two known ones: trametenolic acid and 15α- hydroxytrametenolic acid, have been isolated, identified and proved to selectively inhibit thrombin but not trypsin.
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