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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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5-Sulfonamide Benzimidazoles: A Class of Cannabinoid Receptors Agonists with Potent In Vivo Antinociception Activity
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 3, Mar 2010, p. 208 - 213
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- 01 Mar 2010
Abstract
The synthesis and biological evaluation of a novel class of cannabinoid receptor agonists based on a 5- sulfonamide benzimidazole scaffold are reported. They showed a high binding affinity to both receptors with great in vivo potency. When given orally to rats, they produced a robust analgesia in different models of inflammatory and neuropathic pain.
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