Full text loading...
- ISSN: 1570-1808
- E-ISSN: 1875-628X
-
Hologram QSAR Studies of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides Derivatives as Selective Peripheral Benzodiazepine Receptor Ligands
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 2, Feb 2010, p. 133 - 138
-
- 01 Feb 2010
Abstract
Peripheral benzodiazepine receptor (PBR) is an important target for the development of drugs to treat anxiety and sleep disorders. Hologram QSAR models were built for good statistical results. Contribution map analysis explains the individual atomic contributions to the overall activity. This HQSAR model should be useful for the further development of novel structurally related PBR ligands.
© Bentham Science Publishers