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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Studies on the Pharmacokinetics of Methotrexate by Scintigraphic Monitoring of [99mTc]Pteridinic Derivatives Biodistribution
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 2, Feb 2010, p. 98 - 101
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- 01 Feb 2010
Abstract
Methotrexate (MTX) use associated with optical irradiation of the malignant tumours requires knowledge of its intratumoral retention time. Radioactive Chromatography and absorption spectroscopy confirm synthesizing of 2,4 diamino 6-pertechnetate pterine that pursues MTX biodistribution. Sequential scintigraphy shows an intratumoral MTX retention time of one hour from systemic administration in bolus.
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