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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Homology Modelling of Human E1 Ubiquitin Activating Enzyme
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 1, Jan 2010, p. 57 - 62
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- 01 Jan 2010
Abstract
Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.
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