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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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H3 Receptor Antagonists: Pharmacophore Modeling and its Implications (Supplementry Material)
- Source: Letters in Drug Design & Discovery, Volume 6, Issue 8, Dec 2009, p. 585 - 594
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- 01 Dec 2009
Abstract
Quantitative 3-D pharmacophore model was generated using 30 chemically diverse H3 receptor antagonists and tested for its productiveness using a large test set. It had 2 hydrogen bond acceptor lipids, 1 positive ionizable and 1 hydrophobic feature. Pharmacophore analysis suggested the structural features required for increased H3 receptor activity.
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