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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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New Pyrrole Hydrazones Synthesized and Evaluated In Vitro as Potential Tuberculostatics
- Source: Letters in Drug Design & Discovery, Volume 6, Issue 7, Oct 2009, p. 508 - 517
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- 01 Oct 2009
Abstract
Sixteen hydrazones were synthesized as derivatives of 1H-1-pyrrolylcarbohydrazides. Five products exhibited 68-97% inhibition against Mycobacterium tuberculosis H37Rv at 6.25 μg/mL using MABA, the most active displaying IC50=7.979 μg/mL and IC90>100 μg/mL. Activities correlated with the hydrophobic parameters according to second order QSAR model favoring 4.4 ≥ LogP ≥ 5.2.
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