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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis of Novel Benzoquinones with Anti-Inflammatory Activity
- Source: Letters in Drug Design & Discovery, Volume 6, Issue 3, Apr 2009, p. 172 - 177
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- 01 Apr 2009
Abstract
Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong .OH radical scavenging, whereas benzoquinones with an α- hydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition.
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