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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole Scaffold
- Source: Letters in Drug Design & Discovery, Volume 6, Issue 1, Jan 2009, p. 29 - 32
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- 01 Jan 2009
Abstract
Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.
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