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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Evaluation of 2'-Substituted Fendiline Analogues as Antileukemics
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 4, Jun 2007, p. 246 - 248
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- 01 Jun 2007
Abstract
A series of novel, 2'-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2'-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.
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