Gracilins G-I, Cytotoxic Bisnorditerpenes from Spongionella pulchella, and the Anti-Adhesive Properties of Gracilin B

Ana Rueda; Alejandro Losada; Rogelio Fernandez; Carlos Cabanas; Luis F. Garcia-Fernandez; Fernando Reyes; Carmen Cuevas

doi:10.2174/157018006778631875

ISSN: 1570-1808
E-ISSN: 1875-628X

Gracilins G-I, Cytotoxic Bisnorditerpenes from Spongionella pulchella, and the Anti-Adhesive Properties of Gracilin B
Authors: Ana Rueda¹, Alejandro Losada², Rogelio Fernandez³, Carlos Cabanas⁴, Luis F. Garcia-Fernandez⁵, Fernando Reyes⁶ and Carmen Cuevas⁷
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¹ R & D Department,PharmaMar S.A.U., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. ² R & D Department,PharmaMar S.A.U., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. ³ R & D Department,PharmaMar S.A.U., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. ⁴ R & D Department,PharmaMar S.A.U., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. ⁵ R & D Department,PharmaMar S.A.U., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. ⁶ R & D Department,PharmaMar S.A.U., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. ⁷ R & D Department,PharmaMar S.A.U., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 10, Dec 2006, p. 753 - 760
DOI: https://doi.org/10.2174/157018006778631875
- Available online: 01 Dec 2006

Abstract

The isolation, structural characterization and cytotoxic properties of three new (1-3) and three known (4-6) gracilins, obtained from the sponge Spongionella pulchella is described. Gracilin B (4) exhibited selective, broad spectrum inhibition of integrin-mediated cell adhesion to a variety of physiological substrates.

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2006-12-01

2025-09-27

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Article Type: Research Article

Keyword(s): Adhesion inhibitor; Anticancer agent; Gracilin; Integrin; Sponge metabolites; Spongionella pulchella

Gracilins G-I, Cytotoxic Bisnorditerpenes from Spongionella pulchella, and the Anti-Adhesive Properties of Gracilin B

Abstract

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