Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis

W. J. Burke; S. W. Li; K. N. Gillespie; H. D. Chung; K. Jagadeesan; J. H. Joist

doi:10.2174/157018006778194880

ISSN: 1570-1808
E-ISSN: 1875-628X

Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis
Authors: W. J. Burke¹, S. W. Li², K. N. Gillespie³, H. D. Chung⁴, K. Jagadeesan⁵ and J. H. Joist⁶
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¹ Department of Neurology, Saint Louis University Medical School, 3635 Vista at Grand, St. Louis, MO 63110, USA. ² Department of Neurology, Saint Louis University Medical School, 3635 Vista at Grand, St. Louis, MO 63110, USA. ³ Department of Neurology, Saint Louis University Medical School, 3635 Vista at Grand, St. Louis, MO 63110, USA. ⁴ Department of Neurology, Saint Louis University Medical School, 3635 Vista at Grand, St. Louis, MO 63110, USA. ⁵ Department of Neurology, Saint Louis University Medical School, 3635 Vista at Grand, St. Louis, MO 63110, USA. ⁶ Department of Neurology, Saint Louis University Medical School, 3635 Vista at Grand, St. Louis, MO 63110, USA.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 7, Sep 2006, p. 481 - 487
DOI: https://doi.org/10.2174/157018006778194880
- Available online: 01 Sep 2006

Abstract

Free radical damage to endothelial cells is implicated in the pathogenesis of arteriosclerosis. We show that platelet monoamine oxidase (MAO) synthesizes 3,4-dihydroxyphenylglycolaldeyde (DOPEGAL), the free radical generating metabolite of norepinephrine (NE). Platelet synthesis of DOPEGAL could contribute to arteriosclerosis and provide a target for protective therapy to prevent arteriosclerosis in medical conditions with elevated NE levels.

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2006-09-01

2025-09-05

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Article Type: Research Article

Keyword(s): 3,4-dihydroxyphenylglycolaldehyde; Arteriosclerosis; Free radicals; Monoamine oxidase; Platelets

Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis

Abstract

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