Microtubules and Commuting Receptors

M. Modriansky; J. Ulrichova; Z. Dvorak

doi:10.2174/157018006778194718

ISSN: 1570-1808
E-ISSN: 1875-628X

Microtubules and Commuting Receptors
Authors: M. Modriansky¹, J. Ulrichova² and Z. Dvorak³
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¹ Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic. ² Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic. ³ Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 8, Oct 2006, p. 567 - 568
DOI: https://doi.org/10.2174/157018006778194718
- Available online: 01 Oct 2006

Abstract

Receptors that undergo nucleo-cytoplasmic shuttling require microtubules for proper physiologic function. Is it the collapse of microtubules network or simply the arrest of cell cycle in G2/M phase that changes receptors function? The terms of disengagement and the integrity versus dynamics of the microtubules shall guide the ideal drug design.

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2006-10-01

2025-09-04

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Article Type: Research Article

Keyword(s): Cytoskeleton; Drug metabolism; Nuclear receptors; Transcriptional regulation

Microtubules and Commuting Receptors

Abstract

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