Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

Vladimira Moulisova; Jiri Sebestian; Olga Jedlickova; Alexandr Jegorov; Stepanka B. Sebestianova

doi:10.2174/157018006777805567

ISSN: 1570-1808
E-ISSN: 1875-628X

Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids
Authors: Vladimira Moulisova¹, Jiri Sebestian², Olga Jedlickova³, Alexandr Jegorov⁴ and Stepanka B. Sebestianova⁵
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¹ Department of Autotrophic Microorganisms, Institute of Microbiology ASCR, Opatovicky mlyn 379 81 Trebon, Czech Republic. ² Department of Autotrophic Microorganisms, Institute of Microbiology ASCR, Opatovicky mlyn 379 81 Trebon, Czech Republic. ³ Department of Autotrophic Microorganisms, Institute of Microbiology ASCR, Opatovicky mlyn 379 81 Trebon, Czech Republic. ⁴ Department of Autotrophic Microorganisms, Institute of Microbiology ASCR, Opatovicky mlyn 379 81 Trebon, Czech Republic. ⁵ Department of Autotrophic Microorganisms, Institute of Microbiology ASCR, Opatovicky mlyn 379 81 Trebon, Czech Republic.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 6, Aug 2006, p. 429 - 435
DOI: https://doi.org/10.2174/157018006777805567
- Available online: 01 Aug 2006

Abstract

Interactions between cyclosporin A and three silymarin flavonoids (silybin, silydianin, and silychristin) were studied on the rat hepatocyte plasma membrane using the replacement of [3H]cyclosporin A by silymarin flavonoids. It was found that flavonoids significantly replaced CsA from its binding to the rat hepatocyte plasma membrane. It seems that these two types of compounds are competitors at the same binding site of the plasma membrane receptor.

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2006-08-01

2025-09-28

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Article Type: Research Article

Keyword(s): Cyclosporin A; hepatocytes; membrane transport; silymarin flavonoids

Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

Abstract

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