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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis
- Source: Letters in Drug Design & Discovery, Volume 3, Issue 6, Aug 2006, p. 413 - 418
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- 01 Aug 2006
Abstract
In the last five years we prepared and studied some dialkylaminoalkylnaphthalenes and cycloaminoalkylnaphthalenes with interesting opioid-like analgesic activity. In this paper we report on their lipophilicity evaluation combining computational and RP-HPLC experiments. A suitable computational method for the high-throughput log P screening was identified.
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