Target Structure-based Modeling of the Glutamate Transporter Pharmacophore

A. Simon; A. Bencsura; J. Kardos

doi:10.2174/157018006777574230

ISSN: 1570-1808
E-ISSN: 1875-628X

Target Structure-based Modeling of the Glutamate Transporter Pharmacophore
Authors: A. Simon¹, A. Bencsura² and J. Kardos³
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¹ Pusztaszeri ut 59-67., H-1025 Budapest, Hungary. ² Pusztaszeri ut 59-67., H-1025 Budapest, Hungary. ³ Pusztaszeri ut 59-67., H-1025 Budapest, Hungary.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 5, Jul 2006, p. 293 - 297
DOI: https://doi.org/10.2174/157018006777574230
- Available online: 01 Jul 2006

Abstract

Comparison of binding interactions of a bacterial Glu transporter homologue and the extracellular binding domain of metabotropic Glu receptor subtype (mGlu1) showed Glu adopting bent and extended conformations in Glu transporter and mGlu1, respectively.

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2006-07-01

2025-09-09

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Article Type: Research Article

Keyword(s): 4-PDC; docking and molecular dynamics; GABA; glutamate; Glutamate transporter; L-trans-2; metabotropic Glu receptor subtype 1

Target Structure-based Modeling of the Glutamate Transporter Pharmacophore

Abstract

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